SCHEMBL1532945

SCHEMBL1532945

Clc1ccc([C]c2ccc(Cl)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.57
CYP2A6 P11509 1/20 0.57
MAOA P21397 2/20 0.44
MAOB P27338 2/20 0.44
IDO1 P14902 2/20 0.42
KCNH2 Q12809 1/20 0.39
TSHR P16473 5/20 0.39
CYP1A2 P05177 1/20 0.38
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
NLRP3 Q96P20 1/20 0.37
MAPK1 P28482 3/20 0.36
CYP3A4 P08684 2/20 0.36
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
ENPP2 Q13822 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MIF P14174 1/20 0.36
GRM5 P41594 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3839221 0.88 TSHR (0.53) LMNACYP2A6MAOAMAOBIDO1
SCHEMBL3081356 0.80
SCHEMBL719360 0.79 LMNA (0.57) LMNACYP2A6MAOAMAOBIDO1
SCHEMBL20015814 0.79 LMNA (0.57) LMNACYP2A6MAOAMAOBIDO1
SCHEMBL18050317 0.79 LMNA (0.57) LMNACYP2A6MAOAMAOBIDO1
SCHEMBL18050316 0.79 LMNA (0.57) LMNACYP2A6MAOAMAOBIDO1
1,4-Dichlorobenzene SCHEMBL28118904 0.77 LMNA (0.67) LMNACYP2A6IDO1TSHRCYP1A2
Charcoal, Activated SCHEMBL31286310 0.76 KCNH2 (0.54) LMNACYP2A6MAOAMAOBIDO1
1,4-Dichlorobenzene SCHEMBL11243685 0.76
1,4-Dichlorobenzene SCHEMBL5191 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10618987-B2 Modified catalyst supports TOTAL RESEARCH & TECHNOLOGY FELUY (BE) 2020-04-14 US claimed
US-20190161565-A1 Modified Catalyst Supports TOTAL RES & TECHNOLOGY FELUY (BE) 2019-05-30 US claimed
US-10233268-B2 Modified catalyst supports TOTAL RESEARCH & TECHNOLOGY FELUY (BE) 2019-03-19 US claimed
US-8445607-B2 Process for the preparation of a particulate bimodal polyethylene product TOTAL RESEARCH & TECHNOLOGY FELUY (BE) 2013-05-21 US claimed
US-20120245307-A1 PROCESS FOR THE PREPARATION OF A PARTICULATE BIMODAL POLYETHYLENE PRODUCT TOTAL PETROCHEMICALS RESEARCH FELUY (BE) 2012-09-27 US claimed
EP-0465254-B1 Fused thiophene compounds and uses thereof YOSHITOMI PHARMACEUTICAL (JP) 1996-11-13 EP claimed
US-5466691-A Antipsychotic and anxiolytic agents YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1995-11-14 US claimed
US-5141930-A Antianxietic drug, antipsychotics and cardiotonic agents YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1992-08-25 US claimed
US-11613595-B2 Ethylene alpha-olefin non-conjugated polyene copolymer, use thereof, and manufacturing method thereof MITSUI CHEMICALS, INC. (JP) 2023-03-28 US disclosed
US-20210122860-A1 ETHYLENE ALPHA-OLEFIN NON-CONJUGATED POLYENE COPOLYMER, USE THEREOF, AND MANUFACTURING METHOD THEREOF MITSUI CHEMICALS, INC. (JP) 2021-04-29 US disclosed
US-10618987-B2 Modified catalyst supports TOTAL RESEARCH & TECHNOLOGY FELUY (BE) 2020-04-14 US disclosed
US-10435494-B2 Ethylene/α-olefin/non-conjugated polyene copolymer, and production process and use thereof MITSUI CHEMICALS, INC. (JP) 2019-10-08 US disclosed
US-20190161565-A1 Modified Catalyst Supports TOTAL RES & TECHNOLOGY FELUY (BE) 2019-05-30 US disclosed
US-10233268-B2 Modified catalyst supports TOTAL RESEARCH & TECHNOLOGY FELUY (BE) 2019-03-19 US disclosed
US-5532240-A ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1996-07-02 US disclosed
US-5466691-A Antipsychotic and anxiolytic agents YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1995-11-14 US disclosed
EP-0596120-A1 THIOPHENE COMPOUND YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-05-11 EP disclosed
EP-0596125-A1 CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-05-11 EP disclosed
US-5141930-A Antianxietic drug, antipsychotics and cardiotonic agents YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1992-08-25 US disclosed
EP-0465254-A1 Fused thiophene compounds and uses thereof YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1992-01-08 EP disclosed