Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | CASP3 | P42574 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609658 | 0.74 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL5660084 | 0.73 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL14562709 | 0.73 | NR1H4 (0.57) | NPC1RAB9ASMN1; SMN2CASP3TP53 | |
| SCHEMBL5660080 | 0.73 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL4743094 | 0.71 | CASP3 (0.56) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL13930846 | 0.70 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL28882633 | 0.70 | CASP3 (0.65) | NPC1RAB9ASMN1; SMN2CASP3TP53 | |
| SCHEMBL12385450 | 0.69 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL15013375 | 0.69 | CASP3 (0.54) | NPC1RAB9ASMN1; SMN2TSHRCASP3 | |
| SCHEMBL91494 | 0.69 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2TSHRCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3540059-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2019-09-18 | — | — | EP | disclosed |
| EP-2558577-B1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION AS (DK) | 2018-12-12 | — | — | EP | disclosed |
| US-20130281324-A1 | BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2013-10-24 | — | — | US | disclosed |