SCHEMBL15330993

SCHEMBL15330993

CCc1nn(-c2ccc(Cl)cc2)c(Cl)c1C=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.41
PTGS2 P35354 3/20 0.40
PTGS1 P23219 2/20 0.40
LMNA P02545 1/20 0.38
THRB P10828 1/20 0.38
KMT2A Q03164 3/20 0.38
NOTUM Q6P988 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
GAA P10253 1/20 0.36
NR3C1 P04150 1/20 0.36
MEN1 O00255 2/20 0.36
MALT1 Q9UDY8 1/20 0.36
GPBAR1 Q8TDU6 1/20 0.36
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 3/20 0.35
HPGD P15428 3/20 0.35
USP2 O75604 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15332734 0.90 MAPT (0.41) MAPTPTGS2LMNAKMT2ASMN1; SMN2
SCHEMBL15331734 0.88 MAPT (0.40) MAPTPTGS2LMNAKMT2ASMN1; SMN2
SCHEMBL15330859 0.88 MAPT (0.44) MAPTLMNAKMT2ASMN1; SMN2RAB9A
SCHEMBL15330703 0.88 MAPT (0.40) MAPTPTGS2PTGS1LMNATHRB
SCHEMBL29953708 0.88 SMN1; SMN2 (0.47) MAPTLMNAKMT2ASMN1; SMN2RAB9A
SCHEMBL29952221 0.87 KHK (0.38) MAPTLMNAKMT2ASMN1; SMN2RAB9A
SCHEMBL15331546 0.85 GAA (0.39) MAPTLMNATHRBKMT2ASMN1; SMN2
SCHEMBL15332156 0.84 GAA (0.40) MAPTLMNATHRBSMN1; SMN2GAA
SCHEMBL15331553 0.84 PTGS2 (0.40) MAPTPTGS2PTGS1LMNATHRB
SCHEMBL15331454 0.84 KMT2A (0.47) MAPTLMNAKMT2ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed