Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310023 | 0.78 | MAPT (0.47) | KDM4EHPGDHSD17B10SLC22A12MAPT | |
| SCHEMBL27053061 | 0.73 | KDM4E (0.44) | ELANEKDM4EHPGDHSD17B10MRGPRX4 | |
| SCHEMBL3107355 | 0.71 | NOTUM (0.40) | KDM4EHPGDHSD17B10XDHSLC22A12 | |
| SCHEMBL1914042 | 0.70 | KDM4E (0.67) | ELANEKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL29574839 | 0.70 | KDM4E (0.67) | ELANEKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL2650251 | 0.70 | CSNK2A1 (0.44) | ELANEXDHSLC22A12NOTUMALDH1A1 | |
| SCHEMBL28314003 | 0.69 | ALDH1A1 (0.39) | KDM4EHSD17B10MAPTNOTUMGRIA2 | |
| SCHEMBL22408774 | 0.69 | TDP1 (0.47) | ELANEKDM4EHPGDHSD17B10MRGPRX4 | |
| SCHEMBL8141458 | 0.68 | NOTUM (0.49) | KDM4EHPGDMRGPRX4MAPTTDP1 | |
| SCHEMBL28992458 | 0.68 | EPAS1 (0.41) | KDM4EEPAS1MAPTNOTUMGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470500-A2 | TETRACYCLINE COMPOUNDS | Tetraphase Pharmaceuticals, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025982-A2 | TETRACYCLINE COMPOUNDS | TETRAPHASE PHARMACEUTICALS, INC. (US) | 2011-03-03 | — | — | WO | disclosed |