Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | HAAO | P46952 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28992453 | 0.83 | KDM4E (0.36) | NOTUMKDM4EHSD17B10ALOX15CYP1A2 | |
| SCHEMBL2650251 | 0.83 | CSNK2A1 (0.44) | NOTUMALDH1A1MCL1TSHRMEN1 | |
| SCHEMBL8141458 | 0.81 | NOTUM (0.49) | NOTUMKDM4ECYP1A2ALDH1A1HPGD | |
| SCHEMBL28314005 | 0.81 | CYP1A2 (0.33) | NOTUMKDM4EHSD17B10ALOX15CYP1A2 | |
| SCHEMBL28315220 | 0.80 | ALDH1A1 (0.48) | KDM4EHSD17B10CYP1A2ALDH1A1HPGD | |
| SCHEMBL4696826 | 0.79 | KDM4E (0.48) | NOTUMHAAOKDM4EHSD17B10CYP1A2 | |
| SCHEMBL28314003 | 0.79 | ALDH1A1 (0.39) | NOTUMKDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL310023 | 0.79 | MAPT (0.47) | NOTUMKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL28363838 | 0.79 | CYP1A2 (0.52) | NOTUMKDM4EALOX15CYP1A2ALDH1A1 | |
| SCHEMBL400759 | 0.78 | NOTUM (0.43) | NOTUMHAAOCYP1A2GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105492434-B | Miscellaneous bicyclic aryl RORC2 inhibitor and its application method | 辉瑞大药厂 | 2018-02-16 | — | — | CN | disclosed |
| US-20100179140-A1 | INDENOISOQUINOLINONE ANALOGS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179140-A1 | INDENOISOQUINOLINONE ANALOGS AND METHODS OF USE THEREOF | TNNI3, IDH2, GLS | NOTUM 3278/4885HAAO 903/4885KDM4E 2660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.