SCHEMBL15340752

SCHEMBL15340752

CCc1cnc(N2CC[C@@H](c3nc(COc4ccc(-n5cnnn5)nc4)cs3)[C@@H](C)C2)nc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.66
KCNJ1 P48048 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19844159 0.92 GPR119 (0.78) GPR119
SCHEMBL11885633 0.92 GPR119 (0.78) GPR119
SCHEMBL3487527 0.92 GPR119 (0.78) GPR119
SCHEMBL1118409 0.89 GPR119 (0.83) GPR119KCNJ1
SCHEMBL8022934 0.84 GPR119 (0.65) GPR119
SCHEMBL1118305 0.84 GPR119 (0.65) GPR119
SCHEMBL1118200 0.82 GPR119 (0.91) GPR119
SCHEMBL1118607 0.81 GPR119 (0.71) GPR119KCNJ1
Mbx-2982 SCHEMBL1118326 0.80 GPR119 (1.00) GPR119
SCHEMBL3685203 0.79 GPR119 (0.49) GPR119KCNJ1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130281691-A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS CYMABAY THERAPEUTICS, INC. 2013-10-24 US disclosed
US-20130281691-A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS CYMABAY THERAPEUTICS, INC. 2013-10-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130281691-A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS GPR119, INSR, GLP1R GPR119 1/4885KCNJ1 1458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.