Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.44 |
| ▸ | PTPRC | P08575 | 3/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.44 |
| ▸ | PTPN9 | P43378 | 3/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.44 |
| ▸ | EPM2A | O95278 | 1/20 | 0.44 |
| ▸ | PTPRG | P23470 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1534645 | 0.90 | KDM4E (0.52) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534565 | 0.83 | ALDH1A1 (0.74) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534630 | 0.79 | MAOB (0.55) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534705 | 0.76 | BCHE (0.51) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1423181 | 0.75 | KMT2A (0.65) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL12273995 | 0.74 | CA1 (0.43) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534478 | 0.74 | ACHE (0.49) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534543 | 0.73 | ALDH1A1 (0.74) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL22247537 | 0.72 | MAOB (0.44) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534460 | 0.71 | MEN1 (0.58) | ALDH1A1MAPTCYP3A4KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546376-B2 | Pharmaceutical compounds | ALMAC DISCOVERY LIMITED (GB) | 2013-10-01 | — | — | US | disclosed |
| US-20120238541-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2012-09-20 | — | — | US | disclosed |
| EP-2473495-A1 | PHARMACEUTICAL COMPOUNDS | Almac Discovery Limited (GB) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011033265-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238541-A1 | PHARMACEUTICAL COMPOUNDS | PIK3CA, PLK1, MTOR | ALDH1A1 4088/4885MAPT 640/4885CYP3A4 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.