Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.60 |
| ▸ | NCK1 | P16333 | 1/20 | 0.60 |
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7229411 | 0.88 | BACE1 (0.47) | BACE1NCK1CTSDCCR1CCR5 | |
| SCHEMBL15341749 | 0.81 | BACE1 (0.48) | BACE1NCK1CTSDPLAUNCF1 | |
| SCHEMBL15344931 | 0.81 | CCR1 (0.46) | BACE1NCK1CCR1CCR5CCR8 | |
| SCHEMBL27960700 | 0.81 | CCR1 (0.46) | BACE1NCK1CCR1CCR5CCR8 | |
| SCHEMBL15344999 | 0.79 | HPGD (0.46) | CCR1CCR5CCR8MEN1KMT2A | |
| SCHEMBL27960667 | 0.79 | BACE1 (0.60) | BACE1NCK1CTSDCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL7240078 | 0.77 | CCR1 (0.44) | BACE1NCK1CCR1CCR5CCR8 | |
| SCHEMBL7048523 | 0.76 | BACE1 (1.00) | BACE1NCK1CTSDPLAUKDM4E | |
| SCHEMBL15345083 | 0.76 | BACE1 (0.52) | BACE1NCK1CTSDPLAUKDM4E | |
| SCHEMBL16805027 | 0.76 | CCR1 (0.55) | CCR1CCR5CCR8KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574835-B | Compounds for the treatment of cancer | SPLICOS SOC | 2014-04-16 | — | — | CN | claimed |
| EP-3070081-B1 | BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES INC (US) | 2018-02-28 | — | — | EP | disclosed |
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-01-21 | — | — | US | disclosed |
| US-8987250-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| CN-103948594-A | Compounds for the treatment of cancer | SPLICOS SOC | 2014-07-30 | — | — | CN | disclosed |
| CN-102574835-B | Compounds for the treatment of cancer | SPLICOS SOC | 2014-04-16 | — | — | CN | disclosed |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | BACE1 386/4885NCK1 937/4885CTSD 1314/4885 |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | BACE1 386/4885NCK1 937/4885CTSD 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.