Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 3/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16841639 | 0.88 | HPGD (0.45) | IGF1RTYRO3PTGDRHPGDAKT3 | |
| SCHEMBL15358312 | 0.86 | HDAC3 (0.58) | TYRO3GPR84STAT6HDAC3HDAC1 | |
| SCHEMBL15358316 | 0.83 | HDAC3 (0.56) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15358313 | 0.82 | HDAC3 (0.50) | TYRO3HPGDSTAT6KMT2AHDAC3 | |
| SCHEMBL15358320 | 0.80 | STAT6 (0.54) | STAT6KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL15358321 | 0.80 | HDAC3 (0.57) | TYRO3STAT6HDAC3HDAC1HDAC2 | |
| SCHEMBL11084759 | 0.76 | STAT6 (0.58) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11089737 | 0.76 | VNN1 (0.55) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4089718 | 0.76 | CA1 (0.53) | GPR84TAAR1HPGDCNR1KMT2A | |
| SCHEMBL15358452 | 0.75 | HDAC3 (0.57) | STAT6HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890126-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF) | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890126-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF) | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160257655-A1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS (ISPF) | NORTHERN ILLINOIS RESEARCH FOUNDATION | 2016-09-08 | — | — | US | disclosed |
| US-20160257655-A1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS (ISPF) | NORTHERN ILLINOIS RESEARCH FOUNDATION | 2016-09-08 | — | — | US | disclosed |
| US-9309232-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2016-04-12 | — | — | US | disclosed |
| US-9309232-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2016-04-12 | — | — | US | disclosed |
| US-20150175582-A1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS | Board of Trustees of Nothern Illinois University (US) | 2015-06-25 | — | — | US | disclosed |
| US-20150175582-A1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS | Board of Trustees of Nothern Illinois University (US) | 2015-06-25 | — | — | US | disclosed |
| WO-2013163159-A2 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2013-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175582-A1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS | COASY, GGPS1, FDPS | IGF1R 2549/4885TYRO3 4729/4885GPR84 4372/4885 |
| US-20160257655-A1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS (ISPF) | COASY, GGPS1, FDPS | IGF1R 3074/4885TYRO3 4694/4885GPR84 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.