Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15399429 | 0.85 | MEN1 (0.40) | TSHRKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL2392136 | 0.84 | CYP2B6 (0.59) | CYP2B6TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL2491599 | 0.82 | CYP2B6 (0.63) | CYP2B6TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL19296941 | 0.82 | CYP2B6 (0.63) | CYP2B6TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL27753492 | 0.80 | CYP2B6 (0.54) | CYP2B6TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL2495637 | 0.78 | ESR1 (0.53) | CYP2B6TSHRKDM4EKMT2ASLC6A2 | |
| SCHEMBL2489520 | 0.76 | CYP2B6 (0.56) | CYP2B6HRH3TSHRKDM4EKMT2A | |
| SCHEMBL27544718 | 0.76 | ESR1 (0.52) | CYP2B6KDM4EKMT2AMEN1HPGD | |
| SCHEMBL12199488 | 0.76 | CYP2B6 (0.56) | CYP2B6HRH3TSHRKDM4EKMT2A | |
| SCHEMBL12209773 | 0.76 | CYP2B6 (0.51) | CYP2B6KMT2AMEN1HPGDKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871507-B2 | Method of inhibiting apolipoprotein-E expression comprising administering a triarylmethyl amine compound | CALIFORNIA STATE UNIVERSITY, FRESNO (US) | 2014-10-28 | — | — | US | disclosed |
| US-20140080209-A1 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND | CALIFORNIA STATE UNIVERSITY FRESNO (US) | 2014-03-20 | — | — | US | disclosed |
| US-8633195-B1 | Method of inhibiting apolipoprotein-E expression comprising administering a triarylmethyl amine compound | Fresno California State University (US) | 2014-01-21 | — | — | US | disclosed |
| US-20140005196-A1 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND | California State University Fullerton (US) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005196-A1 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND | APOB, APOL1, LDLR | CYP2B6 339/4885HRH3 476/4885MCOLN3 4794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.