SCHEMBL15412440

SCHEMBL15412440

Cn1c(-c2ccc(Cl)cc2F)nc2cc(C(F)(F)F)cnc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 4/20 0.48
▸ POLB P06746 1/20 0.42
▸ TNKS O95271 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.37
▸ KCNH2 Q12809 1/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ TRPM5 Q9NZQ8 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ XBP1 P17861 1/20 0.37
▸ PPARG P37231 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ NCOA2 Q15596 1/20 0.37
▸ NCOA1 Q15788 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ NCOA3 Q9Y6Q9 1/20 0.37
▸ PDE2A O00408 2/20 0.36
▸ CNR2 P34972 1/20 0.36
▸ GRIN2B Q13224 1/20 0.36
▸ HDAC1 Q13547 1/20 0.36
▸ HDAC8 Q9BY41 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10280804 0.89 HSD11B1 (0.48) HSD11B1POLBPDE2AHDAC1HDAC8
SCHEMBL10280803 0.88 POLB (0.43) HSD11B1POLBLMNAHTTSMN1; SMN2
SCHEMBL15412915 0.86 POLB (0.42) HSD11B1POLBALDH1A1HTTSMN1; SMN2
SCHEMBL9953426 0.84 PDE2A (0.49) HSD11B1POLBALDH1A1PDE2A
SCHEMBL10280741 0.84 POLB (0.43) HSD11B1POLBSMN1; SMN2PDE2AHDAC1
SCHEMBL10280808 0.83 POLB (0.48) HSD11B1POLBPDE2AHDAC1HDAC8
SCHEMBL10280699 0.83 POLB (0.48) HSD11B1POLBTNKSALDH1A1KCNH2
SCHEMBL16667035 0.83 POLB (0.42) HSD11B1POLBPDE2AHDAC1HDAC8
SCHEMBL10281064 0.83 HSD11B1 (0.41) HSD11B1POLBALDH1A1PPARGNCOA2
SCHEMBL16002372 0.83 POLB (0.40) HSD11B1POLBKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006429-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2019-02-06 — — EP disclosed
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 — — EP disclosed
EP-3006429-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO., LTD. (JP) 2016-04-13 — — EP disclosed
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 — — US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 — — US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 — — US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 HSD11B1 1704/4885POLB 4715/4885TNKS 4731/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 HSD11B1 1639/4885POLB 4737/4885TNKS 4726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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