SCHEMBL154135

SCHEMBL154135

COC(=O)c1ccccc1-n1cc(O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O)c2c(Cl)c(Br)ccc21

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.35
POLB P06746 1/20 0.34
APP P05067 2/20 0.33
SLC5A2 P31639 1/20 0.32
LDHA P00338 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL155033 0.92 SLC28A3 (0.34) SLC5A2
SCHEMBL154137 0.90 APP (0.41) POLBAPPSLC5A2LDHA
SCHEMBL154136 0.90 APP (0.41) POLBAPPSLC5A2LDHA
SCHEMBL28795196 0.90 APP (0.41) POLBAPPSLC5A2LDHA
SCHEMBL155666 0.89 HK1 (0.33) POLBSLC5A2
SCHEMBL153142 0.86 SLC5A2 (0.34) APPSLC5A2
SCHEMBL156208 0.83 NR4A2 (0.43) POLBAPPSLC5A2LDHA
SCHEMBL153740 0.83 MAPK8 (0.39) POLBSLC5A2
SCHEMBL155034 0.82 SLC28A3 (0.45) SLC5A2
SCHEMBL155035 0.82 SLC28A3 (0.45) SLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8940909-B2 Indicator platform BIOSYNTH AG (CH) 2015-01-27 US disclosed
EP-2427431-B1 NOVEL INDICATOR PLATFORM BIOSYNTH AG (CH) 2013-05-01 EP disclosed
US-20120058503-A1 Novel Indicator Platform BIOSYNTH AG (CH) 2012-03-08 US disclosed
EP-2256103-A1 Novel indicator platform Biosynth AG (CH) 2010-12-01 EP disclosed