Sugi Predict

Sugi Predict / Compounds / SCHEMBL15415537

SCHEMBL15415537

SCHEMBL15415537

CC1CNCCN1C(=O)c1[c]nccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 1/20 0.40
▸ PAK4 O96013 4/20 0.37
▸ PLD1 Q13393 1/20 0.36
▸ PAK1 Q13153 2/20 0.35
▸ PRKD3 O94806 2/20 0.34
▸ PRKCG P05129 2/20 0.34
▸ PRKCB P05771 2/20 0.34
▸ PRKCA P17252 2/20 0.34
▸ PRKACA P17612 2/20 0.34
▸ PRKACG P22612 2/20 0.34
▸ PRKACB P22694 2/20 0.34
▸ PRKCH P24723 2/20 0.34
▸ PRKCI P41743 2/20 0.34
▸ PRKCE Q02156 2/20 0.34
▸ PRKCQ Q04759 2/20 0.34
▸ PRKCZ Q05513 2/20 0.34
▸ PRKCD Q05655 2/20 0.34
▸ PRKD1 Q15139 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3763035 0.81 DPP4 (0.39) DPP4PAK4PLD1MEN1TSHR
SCHEMBL2648627 0.80 DPP4 (0.43) DPP4PAK4PLD1PAK1PRKD3
SCHEMBL15416006 0.77 SIGMAR1 (0.50) KMT2A
SCHEMBL1763154 0.77 CHRNB2 (0.52) DPP4PLD1SMN1; SMN2TSHRHSD17B10
SCHEMBL1763365 0.77 CHRNB2 (0.52) DPP4PLD1SMN1; SMN2TSHRHSD17B10
SCHEMBL7999554 0.77 CHRNB2 (0.52) DPP4PLD1SMN1; SMN2TSHRHSD17B10
Hydrochloric Acid SCHEMBL1948523 0.76 CHRNB2 (0.51) DPP4PLD1SMN1; SMN2TSHRKMT2A
SCHEMBL1763337 0.76 CHRNB2 (0.53) MAPK1ALDH1A1CHRNA7
Hydrochloric Acid SCHEMBL31185488 0.76 CHRNB2 (0.51) DPP4PLD1SMN1; SMN2TSHRKMT2A
SCHEMBL1763339 0.76 CHRNB2 (0.53) MAPK1ALDH1A1CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9550737-B2 TNF -α modulating benzimidazoles UCB BIOPHARMA SPRL (BE) 2017-01-24 — — US disclosed
US-9475820-B2 Substituted imidazo[1,2-a]pyrazines as TNF activity modulators UCB BIOPHARMA SPRL (BE) 2016-10-25 — — US disclosed
US-20150191482-A1 Imidazopyrazine Derivatives as Modulators of TNF Activity UCB BIOPHARMA SPRL (BE) 2015-07-09 — — US disclosed
US-20150152065-A1 TNF -Alpha Modulating Benzimidazoles UCB BIOPHARMA SPRL (BE) 2015-06-04 — — US disclosed
EP-2872511-A1 IMIDAZOPYRAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY UCB Biopharma SPRL (BE) 2015-05-20 — — EP disclosed
EP-2858983-A1 TNF -ALPHA MODULATING BENZIMIDAZOLES UCB Biopharma SPRL (BE) 2015-04-15 — — EP disclosed
WO-2014009296-A1 IMIDAZOPYRAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY UCB PHARMA S.A. (BE) 2014-01-16 — — WO disclosed
WO-2013186229-A1 TNF -ALPHA MODULATING BENZIMIDAZOLES UCB PHARMA S.A. (BE) 2013-12-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150152065-A1 TNF -Alpha Modulating Benzimidazoles TNF, TNFRSF1A, NFKBIA DPP4 557/4885PAK4 2856/4885PLD1 4167/4885
US-20150191482-A1 Imidazopyrazine Derivatives as Modulators of TNF Activity TNF, TNFRSF1A, NFKBIA DPP4 259/4885PAK4 1995/4885PLD1 3749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.