Sugi Predict

Sugi Predict / Compounds / SCHEMBL15415629

SCHEMBL15415629

SCHEMBL15415629

C/C(=C\C(Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.57
▸ CTSS P25774 8/20 0.55
▸ CTSK P43235 7/20 0.55
▸ CTSB P07858 2/20 0.55
▸ CTSL P07711 1/20 0.55
▸ APP P05067 4/20 0.50
▸ ACE P12821 1/20 0.50
▸ SYK P43405 1/20 0.48
▸ PPARA Q07869 1/20 0.48
▸ KLK5 Q9Y337 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2507124 1.00 ATM (0.57) ATMCTSSCTSKCTSBCTSL
SCHEMBL15415630 1.00 ATM (0.57) ATMCTSSCTSKCTSBCTSL
SCHEMBL18765 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL30867 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL28572952 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL45753 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL30865 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL13566632 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL29373190 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL
SCHEMBL30866 0.93 CTSS (0.59) ATMCTSSCTSKCTSBCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-12-05 — — US disclosed
US-11767294-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-09-26 — — US disclosed
EP-3210627-B1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO LTD (CN) 2022-12-21 — — EP disclosed
US-20190330149-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-10-31 — — US disclosed
US-10399941-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-09-03 — — US disclosed
US-10159745-B2 Tubulysin derivatives MEDIMMUNE, LLC (US) 2018-12-25 — — US disclosed
EP-3348280-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2018-07-18 — — EP disclosed
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2018-01-25 — — US disclosed
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2017-10-19 — — US disclosed
EP-3210627-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2017-08-30 — — EP disclosed
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD (CN) 2017-06-08 — — US disclosed
EP-3129362-A1 TUBULYSIN DERIVATIVES Medimmune, LLC (US) 2017-02-15 — — EP disclosed
US-20160339114-A1 TUBULYSIN DERIVATIVES MEDIMMUNE LLC (US) 2016-11-24 — — US disclosed
US-9427479-B2 Tubulysin derivatives MEDIMMUNE LLC (US) 2016-08-30 — — US disclosed
US-20150291657-A1 TUBULYSIN DERIVATIVES MEDIMMUNE LLC (US) 2015-10-15 — — US disclosed
WO-2015157594-A1 TUBULYSIN DERIVATIVES MEDIMMUNE LLC (US) 2015-10-15 — — WO disclosed
EP-2872157-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2015-05-20 — — EP disclosed
WO-2014009774-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD (CN) 2014-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190330149-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS CD4, CD2, CD47 ATM 3020/4885CTSS 1448/4885CTSK 1867/4885
US-10399941-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 ATM 3020/4885CTSS 1448/4885CTSK 1867/4885
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS CD4, CD2, CD47 ATM 2988/4885CTSS 1523/4885CTSK 1843/4885
US-11767294-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 ATM 3020/4885CTSS 1448/4885CTSK 1867/4885
US-10159745-B2 Tubulysin derivatives TEKT1, TWF2, TEK ATM 3553/4885CTSS 1158/4885CTSK 599/4885
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents CD4, CD2, CD47 ATM 3020/4885CTSS 1448/4885CTSK 1867/4885
US-20150291657-A1 TUBULYSIN DERIVATIVES TEKT1, TWF2, TEK ATM 3553/4885CTSS 1158/4885CTSK 599/4885
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents CD4, CD2, CD47 ATM 3020/4885CTSS 1448/4885CTSK 1867/4885
US-20160339114-A1 TUBULYSIN DERIVATIVES TEKT1, TWF2, TEK ATM 3553/4885CTSS 1158/4885CTSK 599/4885
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 ATM 3065/4885CTSS 1483/4885CTSK 1890/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.