Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 8/20 | 0.55 |
| ▸ | CTSK | P43235 | 7/20 | 0.55 |
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15415630 | 1.00 | ATM (0.57) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL15415629 | 1.00 | ATM (0.57) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL18765 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL30867 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL28572952 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL45753 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL30865 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL13566632 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL29373190 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL | |
| SCHEMBL30866 | 0.93 | CTSS (0.59) | ATMCTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791098-B2 | Bioactive pre-tubulysins and use thereof | UNIVERSITAET DES SAARLANDES (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791098-B2 | Bioactive pre-tubulysins and use thereof | UNIVERSITAET DES SAARLANDES (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791098-B2 | Bioactive pre-tubulysins and use thereof | UNIVERSITAET DES SAARLANDES (DE) | 2014-07-29 | — | — | US | disclosed |
| US-20110245295-A1 | BIOACTIVE PRE-TUBULYSINS AND USE THEREOF | UNIVERSITAT DES SAARLANDES (DE) | 2011-10-06 | — | — | US | disclosed |
| US-20110245295-A1 | BIOACTIVE PRE-TUBULYSINS AND USE THEREOF | UNIVERSITAT DES SAARLANDES (DE) | 2011-10-06 | — | — | US | disclosed |
| US-20110245295-A1 | BIOACTIVE PRE-TUBULYSINS AND USE THEREOF | UNIVERSITAT DES SAARLANDES (DE) | 2011-10-06 | — | — | US | disclosed |
| EP-2174947-A1 | Bioactive pre-tubulysins and use thereof | Universität des Saarlandes (DE) | 2010-04-14 | — | — | EP | disclosed |
| WO-2010034724-A1 | BIOACTIVE PRE-TUBULYSINS AND USE THEREOF | Universität des Saarlandes (DE) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245295-A1 | BIOACTIVE PRE-TUBULYSINS AND USE THEREOF | VIP, REN, KLK5 | ATM 4780/4885CTSS 428/4885CTSK 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.