Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15416669 | 0.75 | POLB (0.52) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL15416404 | 0.74 | HDAC8 (0.46) | HTTLMNAKMT2AMEN1DNMT3A | |
| SCHEMBL250172 | 0.72 | HTT (0.66) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL11443588 | 0.72 | KMT2A (0.60) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL857765 | 0.71 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL24110380 | 0.71 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL24110361 | 0.71 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL24110389 | 0.71 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL5133119 | 0.70 | KMT2A (0.57) | HTTSMN1; SMN2LMNASTAT6KMT2A | |
| SCHEMBL11882632 | 0.70 | KMT2A (0.57) | HTTSMN1; SMN2LMNASTAT6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |