Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20604549 | 0.82 | HTT (0.47) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7132708 | 0.78 | ASAH1 (0.55) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL11012986 | 0.76 | NPC1 (0.57) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL15416402 | 0.75 | HTT (0.50) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL32660141 | 0.75 | ASAH1 (0.52) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7790594 | 0.74 | ASAH1 (0.51) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1735988 | 0.74 | ASAH1 (0.55) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL15416672 | 0.73 | LMNA (0.67) | HTTALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL11443588 | 0.73 | KMT2A (0.60) | HTTASAH1KMT2AMEN1ALDH1A1 | |
| SCHEMBL250172 | 0.73 | HTT (0.66) | HTTASAH1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |