Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27341190 | 0.73 | MEN1 (0.58) | HSD17B10MEN1HPGDKMT2AHDAC8 | |
| SCHEMBL5033557 | 0.70 | FDPS (0.36) | FDPS | |
| SCHEMBL15416404 | 0.70 | HDAC8 (0.46) | HSD17B10MEN1HPGDKMT2AGAA | |
| SCHEMBL14638103 | 0.67 | MEN1 (0.64) | HSD17B10MEN1HPGDKMT2AHDAC8 | |
| SCHEMBL9754107 | 0.67 | HSD17B10 (0.54) | HSD17B10MEN1HPGDKMT2AHDAC8 | |
| SCHEMBL12419715 | 0.67 | MEN1 (0.54) | HSD17B10MEN1HPGDKMT2AHDAC8 | |
| SCHEMBL15416402 | 0.67 | HTT (0.50) | HSD17B10MEN1HPGDKMT2AGAA | |
| SCHEMBL1027011 | 0.67 | HPGD (0.68) | HSD17B10MEN1HPGDKMT2AGAA | |
| SCHEMBL2146965 | 0.67 | MEN1 (0.68) | HSD17B10MEN1HPGDKMT2AHDAC8 | |
| SCHEMBL4785512 | 0.67 | MEN1 (0.58) | HSD17B10MEN1HPGDKMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |