SCHEMBL15417372

SCHEMBL15417372

Cc1cc(F)c(F)cc1C(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH1A1 P00352 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
CA2 P00918 2/20 0.37
POLB P06746 2/20 0.37
TYR P14679 2/20 0.37
ALOX15 P16050 3/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
ATP2A2 P16615 1/20 0.36
ATP2A3 Q93084 1/20 0.36
TP53 P04637 1/20 0.34
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
HIF1A Q16665 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CA1 P00915 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12390266 0.87 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL21534502 0.87 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL26872568 0.87 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL15417192 0.83 ALDH1A1 (0.43) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL6371866 0.82 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL26627971 0.81 CYP1A2 (0.33) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL25893646 0.81 CYP1A2 (0.33) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL22380066 0.81 ALOX15 (0.52) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL18176657 0.81 ALOX15 (0.47) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL4822812 0.81 CYP3A4 (0.37) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8623889-B2 Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof GENENTECH, INC. (US) 2014-01-07 US disclosed