Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cysteine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.84 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.84 |
| ▸ | GSR | P00390 | 2/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 6/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cysteine SCHEMBL15418989 | 1.00 | PTGS1 (0.84) | PTGS1SLC7A11GSRCPB2ENPEP | |
| Cysteine SCHEMBL5664971 | 0.92 | PTGS1 (0.80) | PTGS1SLC7A11GSRCPB2ENPEP | |
| Cysteine SCHEMBL5664976 | 0.92 | PTGS1 (0.80) | PTGS1SLC7A11GSRCPB2ENPEP | |
| Cysteine SCHEMBL7898895 | 0.92 | PTGS1 (1.00) | PTGS1SLC7A11GSRENPEPGRIK1 | |
| Cysteine SCHEMBL5705430 | 0.92 | PTGS1 (1.00) | PTGS1SLC7A11GSRENPEPGRIK1 | |
| Cysteine SCHEMBL339562 | 0.92 | PTGS1 (1.00) | PTGS1SLC7A11GSRENPEPGRIK1 | |
| Cysteine SCHEMBL4289403 | 0.92 | — | — | |
| Cysteine SCHEMBL21110883 | 0.92 | PTGS1 (1.00) | PTGS1SLC7A11GSRENPEPGRIK1 | |
| Cysteine SCHEMBL95110 | 0.92 | — | — | |
| Cysteine SCHEMBL1868335 | 0.92 | PTGS1 (1.00) | PTGS1SLC7A11GSRENPEPGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687539-B1 | ANNEXIN V VARIANT, AND PREPARATION AND USE THEREOF | TARGETPHARMA LABORATORIES (CHANGZHOU) CO LTD (CN) | 2017-05-31 | — | — | EP | disclosed |
| US-8975380-B2 | Annexin V variant and its preparation and application | TARGETPHARMA LABORATORIES (CHANGZHOU) CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-20140127736-A1 | ANNEXIN V VARIANT AND ITS PREPARATION AND APPLICATION | TARGETPHARMA LABORATORIES (CHANGZHOU) CO., LTD. (CN) | 2014-05-08 | — | — | US | disclosed |
| EP-2687539-A1 | ANNEXIN V VARIANT, AND PREPARATION AND USE THEREOF | Targetpharma Laboratories (Changzhou) Co., Ltd (CN) | 2014-01-22 | — | — | EP | disclosed |
| CN-103041411-A | 99Tcm-Cys-AnnexinV labeled compound with phosphatidylserine as target spot and labeling process and application thereof | NANJING FIRST HOSPITAL | 2013-04-17 | — | — | CN | disclosed |