Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778751 | 0.80 | NR4A2 (0.55) | TGFBR1 | |
| SCHEMBL3367434 | 0.68 | RAB9A (0.65) | RAB9ANPC1GAAMAPTKDM4E | |
| SCHEMBL3777042 | 0.67 | NR4A2 (0.55) | RAB9ANPC1 | |
| SCHEMBL3369696 | 0.66 | NPC1 (0.45) | RAB9ANPC1GAAMAPTLMNA | |
| SCHEMBL3783096 | 0.66 | NR4A2 (0.78) | — | |
| SCHEMBL3370051 | 0.65 | NPC1 (0.50) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL20955776 | 0.65 | TGFBR1 (0.53) | TGFBR1 | |
| SCHEMBL15418966 | 0.65 | RAB9A (0.52) | RAB9ANPC1GAAMAPTKDM4E | |
| SCHEMBL9967267 | 0.65 | MAPT (0.69) | RAB9ANPC1GRM5GAAMAPT | |
| SCHEMBL15418949 | 0.63 | TP53 (0.40) | RAB9ANPC1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |