Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382306 | 0.86 | EGLN1 (0.67) | EGLN1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL2382301 | 0.86 | EGLN1 (0.67) | EGLN1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL12254437 | 0.82 | EGLN1 (0.64) | EGLN1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL15419072 | 0.81 | L3MBTL1 (0.44) | EGLN1L3MBTL1MEN1KMT2AHIF1A | |
| SCHEMBL15419045 | 0.81 | EGLN1 (0.68) | EGLN1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL15419070 | 0.81 | L3MBTL1 (0.45) | EGLN1L3MBTL1MEN1KMT2AHIF1A | |
| SCHEMBL2385032 | 0.80 | EGLN1 (0.61) | EGLN1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL2385033 | 0.80 | EGLN1 (0.61) | EGLN1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL2384498 | 0.78 | EGLN1 (1.00) | EGLN1HIF1A | |
| SCHEMBL15419151 | 0.77 | GSK3B (0.56) | EGLN1L3MBTL1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-B1 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS AND USES THEREOF | AMGEN INC (US) | 2014-01-22 | — | — | EP | claimed |