Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.53 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.51 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.49 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326875 | 0.83 | ORAI1 (0.81) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL14198876 | 0.83 | TRPC3 (0.69) | ORAI1TRPC3TP53TRPC5MAPT | |
| SCHEMBL3277337 | 0.83 | PTGS2 (0.55) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL19692382 | 0.83 | PTGS2 (0.53) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7570850 | 0.82 | PTGS1 (0.65) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL3558495 | 0.82 | PTGS2 (0.56) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL5212522 | 0.82 | ORAI1 (0.60) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL31566340 | 0.81 | STIM1 (0.46) | ORAI1TRPC3STIM1KDM4EMAPT | |
| SCHEMBL597566 | 0.81 | ALDH1A1 (0.45) | ORAI1TRPC3ESR1ESR2TP53 | |
| SCHEMBL7242808 | 0.80 | ORAI1 (0.60) | ORAI1TRPC3TRPC1STIM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694472-B1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2020-03-11 | — | — | EP | disclosed |
| US-9527807-B2 | Sulfonamide derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-27 | — | — | US | disclosed |
| US-20140024650-A1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024650-A1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | GRIN2A, GRIN2B, SLC1A2 | ORAI1 2127/4885TRPC3 2938/4885TRPC1 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.