Sugi Predict

Sugi Predict / Compounds / SCHEMBL15420532

SCHEMBL15420532

SCHEMBL15420532

Cc1nc(-c2ccc(OC[C@H]3CCOC[C@@H]3NS(C)(=O)=O)cc2)cs1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 4/20 0.44
▸ LMNA P02545 4/20 0.42
▸ MAPK1 P28482 2/20 0.42
▸ ATP4A P20648 2/20 0.39
▸ ATP4B P51164 2/20 0.39
▸ RAB9A P51151 5/20 0.39
▸ NPC1 O15118 3/20 0.39
▸ ALDH1A1 P00352 4/20 0.38
▸ TSHR P16473 2/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ XDH P47989 1/20 0.38
▸ GAA P10253 1/20 0.37
▸ HTT P42858 2/20 0.37
▸ GCK P35557 1/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ KAT7 O95251 1/20 0.37
▸ KAT6A Q92794 1/20 0.37
▸ KAT5 Q92993 1/20 0.37
▸ KAT8 Q9H7Z6 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15420640 0.93 HPGD (0.44) HPGDLMNAMAPK1ATP4AATP4B
SCHEMBL15441488 0.93 HPGD (0.44) HPGDLMNAMAPK1ATP4AATP4B
SCHEMBL15420596 0.92 LMNA (0.43) HPGDLMNAMAPK1ATP4AATP4B
SCHEMBL15420125 0.84 LMNA (0.43) HPGDLMNAMAPK1ATP4AATP4B
SCHEMBL15441274 0.84 LMNA (0.43) HPGDLMNAMAPK1ATP4AATP4B
SCHEMBL15420806 0.84 TP53 (0.44) XDHKAT7KAT5KAT8MAPT
SCHEMBL15420525 0.82 LMNA (0.51) HPGDLMNAMAPK1ATP4AATP4B
SCHEMBL15420395 0.82 XDH (0.38) LMNARAB9ANPC1ALDH1A1XDH
SCHEMBL15420032 0.82 LMNA (0.38) HPGDLMNAMAPK1RAB9ANPC1
SCHEMBL15441241 0.82 LMNA (0.38) HPGDLMNAMAPK1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694472-B1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2020-03-11 — — EP disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF GRIN2A, GRIN2B, SLC1A2 HPGD 2650/4885LMNA 4794/4885MAPK1 1793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.