Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR7 | P34969 | 5/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22930053 | 0.95 | HTR2A (0.60) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL8005045 | 0.89 | HTR2A (0.63) | HTR2AHTR2CHTR7NTSR1PSMB1 | |
| SCHEMBL764347 | 0.89 | HTR2A (0.56) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL18856950 | 0.83 | HTR2A (0.55) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL28550149 | 0.82 | HTR2A (0.54) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL22930065 | 0.82 | HTR2A (0.54) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL15550237 | 0.82 | HTR2A (0.54) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL4939152 | 0.81 | HTR2A (0.56) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL765074 | 0.81 | HTR2A (0.48) | HTR2AHTR2CHTR7NTSR1PLG | |
| SCHEMBL28993624 | 0.80 | HTR2A (0.51) | HTR2AHTR2CHTR7NTSR1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987321-B2 | Lisofylline analogs and methods for use | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140018355-A1 | LISOFYLLINE ANALOGS AND METHODS FOR USE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018355-A1 | LISOFYLLINE ANALOGS AND METHODS FOR USE | LPXN, LCT, SI | HTR2A 917/4885HTR2C 822/4885HTR7 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.