Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ATIC | P31939 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.42 |
| ▸ | SHBG | P04278 | 3/20 | 0.42 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448736 | 0.82 | NPC1L1 (0.55) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| SCHEMBL1542735 | 0.79 | NPC1L1 (0.74) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL20094570 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL21176042 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL19506686 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL24151936 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL2600424 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL23452819 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL10308280 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 | |
| 4-Cholesten 3-One SCHEMBL55896 | 0.76 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307438-B1 | CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2018-03-07 | — | — | EP | disclosed |
| EP-2307438-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | Trophos (FR) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012904-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2010-02-04 | — | — | WO | disclosed |