Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.74 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.68 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.59 |
| ▸ | SHBG | P04278 | 3/20 | 0.59 |
| ▸ | PGR | P06401 | 3/20 | 0.59 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.59 |
| ▸ | AR | P10275 | 3/20 | 0.59 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | SNCA | P37840 | 2/20 | 0.59 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Cholesten 3-One SCHEMBL25996870 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL55896 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL19506686 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL24151936 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL20094570 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL23452819 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL2600424 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL10308280 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL21176042 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E | |
| 4-Cholesten 3-One SCHEMBL1688732 | 0.90 | NPC1L1 (0.79) | NPC1L1PTPN1CYP17A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307438-B1 | CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2018-03-07 | — | — | EP | disclosed |
| US-9447140-B2 | Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method | TROPHOS (FR) | 2016-09-20 | — | — | US | disclosed |
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2011-09-15 | — | — | US | disclosed |
| EP-2307438-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | Trophos (FR) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012904-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | NR1H3, NR1H2, CYP27A1 | NPC1L1 22/4885PTPN1 2452/4885CYP17A1 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.