Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20232208 | 0.86 | BCL6 (0.58) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL2062564 | 0.81 | IGF1R (0.54) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL29190578 | 0.78 | MAPK3 (0.43) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL29190654 | 0.78 | ALK (0.42) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL19203872 | 0.78 | LRRK2 (0.69) | ALKCDK9MAPK10MAPK9AURKA | |
| SCHEMBL24752703 | 0.77 | ALK (0.44) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL30184233 | 0.77 | ALK (0.44) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL28969585 | 0.77 | CDK2 (0.43) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL30833698 | 0.77 | ULK1 (0.43) | ALKULK1CCNA2CDK2CCNK | |
| SCHEMBL29019902 | 0.77 | AURKA (0.46) | ALKULK1CCNA2CDK2CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-A1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | Cephalon, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |