Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15424384 | 0.75 | TSHR (0.47) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13453023 | 0.74 | ALDH1A1 (0.38) | TSHR | |
| SCHEMBL24311520 | 0.74 | ALDH1A1 (0.38) | TSHR | |
| SCHEMBL13771105 | 0.74 | ALDH1A1 (0.38) | TSHR | |
| SCHEMBL17029485 | 0.74 | TSHR (0.40) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13934947 | 0.70 | MEN1 (0.44) | TSHR | |
| SCHEMBL5072064 | 0.64 | TSHR (0.55) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25947955 | 0.63 | TSHR (0.50) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14336754 | 0.63 | SLC18A3 (0.44) | TSHR | |
| SCHEMBL21026 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684880-A1 | DISPIROPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-01-15 | — | — | EP | disclosed |