Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17710180 | 0.76 | MAPT (0.40) | TSHRCYP1A2MEN1POLBKMT2A | |
| SCHEMBL17710174 | 0.76 | PARP1 (0.37) | KMT2AALDH1A1HPGD | |
| SCHEMBL16404557 | 0.75 | CHRM2 (0.35) | — | |
| SCHEMBL15424419 | 0.74 | TSHR (0.40) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1195857 | 0.73 | TSHR (0.64) | TSHRSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL13934947 | 0.70 | MEN1 (0.44) | TSHRCYP1B1CYP1A1CYP1A2MEN1 | |
| SCHEMBL18387696 | 0.69 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL8675407 | 0.69 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL1396587 | 0.69 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL8768288 | 0.69 | TSHR (0.48) | TSHRSLC6A2SLC6A4SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| WO-2012062750-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |