Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | CDKN1A | P38936 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15425351 | 0.81 | CDKN1A (0.52) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL15236250 | 0.77 | PRKCI (0.46) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL15425333 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL15425328 | 0.70 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL10343504 | 0.70 | ALDH1A1 (0.60) | LMNAALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL10250441 | 0.70 | RAB9A (0.53) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL10286463 | 0.69 | PDE4B (0.36) | ALDH1A1HPGDKDM4EMAPTHTT | |
| SCHEMBL15425340 | 0.68 | KMT2A (0.44) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL15425345 | 0.68 | MEN1 (0.53) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL15115630 | 0.68 | ALDH1A1 (0.64) | LMNAALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160002256-A1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS, INC. | 2016-01-07 | — | — | US | disclosed |
| US-9067948-B2 | IRAK inhibitors and uses thereof | NIMBUS IRIS, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-20140018357-A1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS, INC. | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002256-A1 | IRAK INHIBITORS AND USES THEREOF | IRAK2, IRAK4, IRAK1 | SMN1; SMN2 2663/4885LMNA 1757/4885ALDH1A1 3406/4885 |
| US-20140018357-A1 | IRAK INHIBITORS AND USES THEREOF | IRAK2, IRAK4, IRAK1 | SMN1; SMN2 2663/4885LMNA 1757/4885ALDH1A1 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.