SCHEMBL15426451

SCHEMBL15426451

CCSc1ccccc1-c1nc2ncc(C)cc2s1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.38
LMNA P02545 1/20 0.38
BCHE P06276 1/20 0.37
ALOX5AP P20292 1/20 0.37
FEN1 P39748 1/20 0.37
AADAT Q8N5Z0 3/20 0.35
NPC1 O15118 2/20 0.35
ATM Q13315 1/20 0.35
ATR Q13535 1/20 0.34
S1PR1 P21453 1/20 0.34
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
POLB P06746 1/20 0.32
CYP1A2 P05177 1/20 0.32
PDE5A O76074 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
KMT2A Q03164 2/20 0.31
MEN1 O00255 1/20 0.31
GAA P10253 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15412820 0.83 ALOX5AP (0.37) MAPTLMNABCHEALOX5APFEN1
SCHEMBL15426418 0.80 ALOX5AP (0.39) MAPTLMNABCHEALOX5APFEN1
SCHEMBL15426367 0.77 MAPT (0.50) MAPTLMNAALOX5APFEN1NPC1
SCHEMBL17802451 0.77 NPC1 (0.44) LMNABCHEALOX5APFEN1NPC1
SCHEMBL15426453 0.77 ALOX5AP (0.37) MAPTALOX5APFEN1AADATATR
SCHEMBL15426334 0.72 NPC1 (0.35) MAPTLMNABCHEALOX5APFEN1
SCHEMBL16885107 0.71 NPC1 (0.36) BCHEALOX5APFEN1NPC1ATM
SCHEMBL16885128 0.70 NPC1 (0.42) MAPTLMNABCHEALOX5APFEN1
SCHEMBL16885115 0.69 PDE5A (0.44) MAPTLMNABCHEKDM4EALDH1A1
SCHEMBL15426296 0.69 ALOX5AP (0.33) MAPTLMNABCHEALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 MAPT 4670/4885LMNA 1591/4885BCHE 618/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 MAPT 4635/4885LMNA 1629/4885BCHE 623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.