SCHEMBL15426418

SCHEMBL15426418

CCSc1ccccc1-c1nc2cc(C)cnc2s1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.39
FEN1 P39748 1/20 0.39
LMNA P02545 4/20 0.38
MAPT P10636 2/20 0.38
BCHE P06276 1/20 0.37
ALDH1A1 P00352 2/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPC1 O15118 2/20 0.35
ATM Q13315 1/20 0.35
CYP1A2 P05177 1/20 0.35
ATR Q13535 1/20 0.34
ADORA3 P0DMS8 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
KDM4E B2RXH2 2/20 0.32
AHR P35869 1/20 0.32
KIT P10721 1/20 0.32
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11953203 0.85 LMNA (0.32) LMNAMAPTALDH1A1HPGDHTT
SCHEMBL16803713 0.85 DYRK1A (0.33) ALOX5APFEN1LMNAMAPTALDH1A1
SCHEMBL10280795 0.83 ALOX5AP (0.39) ALOX5APFEN1LMNAMAPTBCHE
SCHEMBL15868292 0.83 ALDH1A1 (0.36) LMNAMAPTALDH1A1HPGDHTT
SCHEMBL15426428 0.82 ILK (0.35) ALOX5APFEN1LMNAMAPTSMN1; SMN2
SCHEMBL15426451 0.80 MAPT (0.38) ALOX5APFEN1LMNAMAPTBCHE
SCHEMBL15426367 0.80 MAPT (0.50) ALOX5APFEN1LMNAMAPTALDH1A1
SCHEMBL13470780 0.79 SMN1; SMN2 (0.53) MAPTALDH1A1HPGDSMN1; SMN2NPC1
SCHEMBL15426421 0.77 ALDH1A1 (0.42) ALOX5APFEN1LMNAMAPTALDH1A1
SCHEMBL15426414 0.76 LMNA (0.34) LMNAMAPTALDH1A1HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-28 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 ALOX5AP 2508/4885FEN1 3336/4885LMNA 1591/4885
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SFXN1, OSR1, PIR ALOX5AP 4083/4885FEN1 3840/4885LMNA 3171/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 ALOX5AP 2391/4885FEN1 3449/4885LMNA 1629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.