SCHEMBL15426296

SCHEMBL15426296

CCOCn1c(-c2ccccc2SCC)nc2ncc(C)cc21

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
BCHE P06276 1/20 0.33
NPC1 O15118 1/20 0.33
ATM Q13315 1/20 0.33
SLC2A1 P11166 1/20 0.32
ATR Q13535 1/20 0.32
BRD4 O60885 2/20 0.32
AR P10275 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA1 P30542 1/20 0.31
KDM4E B2RXH2 1/20 0.31
HSD17B10 Q99714 1/20 0.31
LMNA P02545 2/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HPGD P15428 1/20 0.30
MAPT P10636 1/20 0.30
LYN P07948 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15412067 0.87 DDR1 (0.34) ALOX5APFEN1BCHEBRD4KDM4E
SCHEMBL15426334 0.83 NPC1 (0.35) ALOX5APFEN1BCHENPC1ATM
SCHEMBL15426295 0.83 AKT1 (0.38) ALOX5APFEN1BCHENPC1ATM
SCHEMBL20708833 0.78 TRPA1 (0.35) AR
SCHEMBL15412648 0.74 POLB (0.43) ALOX5APFEN1ARADORA3ADORA2A
SCHEMBL15426299 0.73 BRD4 (0.39) ALOX5APFEN1BCHENPC1ATM
SCHEMBL15426277 0.71 AKT1 (0.39) ALOX5APFEN1BCHENPC1ATM
SCHEMBL15426279 0.70 BRD4 (0.40) ALOX5APFEN1BCHENPC1ATM
SCHEMBL15412014 0.70 ALDH1A1 (0.37) ALOX5APFEN1BCHENPC1ATM
SCHEMBL15412355 0.69 AKT1 (0.39) ALOX5APFEN1BCHENPC1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 ALOX5AP 2508/4885FEN1 3336/4885BCHE 618/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 ALOX5AP 2391/4885FEN1 3449/4885BCHE 623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.