SCHEMBL15426499

SCHEMBL15426499

Cc1cnc2c(c1)nc(-c1c(F)cc(Br)cc1F)n2C

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ALOX5AP P20292 1/20 0.31
PDE10A Q9Y233 2/20 0.31
CASP3 P42574 1/20 0.31
AKT1 P31749 2/20 0.31
AKT2 P31751 2/20 0.31
DHODH Q02127 1/20 0.30
PDE2A O00408 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426506 0.88 CYP1A2 (0.35) BRD4HSD17B10PDE10AAKT1AKT2
SCHEMBL15426491 0.84 AKT1 (0.38) BRD4PDE10AAKT1AKT2DHODH
SCHEMBL15427219 0.84 POLB (0.44) HSD17B10PDE10ACASP3PDE2A
SCHEMBL15426492 0.76 PDE2A (0.44) BRD4PDE10APDE2A
SCHEMBL15426496 0.76 KDM4E (0.41) BRD4PDE10AAKT1AKT2DHODH
SCHEMBL15426465 0.74 HSD11B1 (0.41) BRD4PDE10AAKT1AKT2PDE2A
SCHEMBL15426493 0.74 MAP4K1 (0.42) AKT1
SCHEMBL15426501 0.72 HSD11B1 (0.42) BRD4PDE10AAKT1AKT2PDE2A
SCHEMBL15868287 0.72 AKT1 (0.41) BRD4PDE10AAKT1AKT2
SCHEMBL15427218 0.72 POLB (0.46) PDE10ACASP3PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 BRD4 1677/4885HSD17B10 1339/4885ALOX5AP 2508/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 BRD4 1616/4885HSD17B10 1343/4885ALOX5AP 2391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.