SCHEMBL15426748

SCHEMBL15426748

CC(=O)NC1=CC(=O)C=C(Cl)C1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.44
S100A4 P26447 2/20 0.40
HSP90AA1 P07900 3/20 0.39
HSP90AB1 P08238 3/20 0.39
PTK2 Q05397 1/20 0.37
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
LMNA P02545 1/20 0.35
ALDH1A1 P00352 3/20 0.35
RAB9A P51151 2/20 0.34
HTT P42858 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
MAPT P10636 1/20 0.34
ATM Q13315 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NPC1 O15118 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
HSD17B10 Q99714 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6295304 0.77 TDP1 (0.44) TDP1S100A4HSP90AA1HSP90AB1MEN1
SCHEMBL11281004 0.71 TDP1 (0.45) TDP1S100A4HSP90AA1HSP90AB1PTK2
SCHEMBL1603211 0.69 TDP1 (0.43) TDP1S100A4MEN1KMT2ALMNA
SCHEMBL57203 0.68 MEN1 (0.50) TDP1MEN1KMT2AALDH1A1MAPT
SCHEMBL11238262 0.67 TDP1 (0.38) TDP1S100A4PTK2MEN1KMT2A
Hydrochloric Acid SCHEMBL28288248 0.66 MEN1 (0.48) TDP1MEN1KMT2AALDH1A1MAPT
SCHEMBL12242961 0.65 HSP90AA1 (0.53) S100A4HSP90AA1HSP90AB1MEN1KMT2A
SCHEMBL11241564 0.64 TDP1 (0.42) TDP1S100A4HSP90AA1HSP90AB1MEN1
SCHEMBL8102187 0.63 RAB9A (0.51) TDP1S100A4HSP90AA1HSP90AB1MEN1
SCHEMBL14386783 0.63 TDP1 (0.49) TDP1S100A4MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2684598-B1 METHOD FOR IMPROVING BLOCKING RATE OF REVERSE OSMOSIS MEMBRANE, AND USE OF A TREATMENT AGENT FOR IMPROVING BLOCKING RATE OF A REVERSE OSMOSIS MEMBRANE KURITA WATER IND LTD (JP) 2019-05-01 EP disclosed
US-9498754-B2 Method for improving rejection of reverse osmosis membrane, treatment agent for improving rejection, and reverse osmosis membrane KURITA WATER INDUSTRIES LTD. (JP) 2016-11-22 US disclosed
EP-2684598-A1 METHOD FOR IMPROVING BLOCKING RATE OF REVERSE OSMOSIS MEMBRANE, TREATMENT AGENT FOR IMPROVING BLOCKING RATE, AND REVERSE OSMOSIS MEMBRANE Kurita Water Industries Ltd. (JP) 2014-01-15 EP disclosed