Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 5/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128668 | 1.00 | CYP3A4 (0.55) | CYP3A4TRPV1PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL1543237 | 0.88 | CYP3A4 (0.68) | CYP3A4TRPV1PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL1543239 | 0.88 | CYP3A4 (0.68) | CYP3A4TRPV1PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL2127133 | 0.83 | CYP3A4 (0.48) | CYP3A4TRPV1PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL2127134 | 0.83 | CYP3A4 (0.48) | CYP3A4TRPV1PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL2127754 | 0.81 | CYP3A4 (0.78) | CYP3A4PIP4K2APIP4K2BPIP4K2CPDPK1 | |
| SCHEMBL1543171 | 0.81 | CYP3A4 (0.78) | CYP3A4PIP4K2APIP4K2BPIP4K2CPDPK1 | |
| SCHEMBL1542857 | 0.80 | CYP3A4 (0.56) | CYP3A4TRPV1PDPK1ABL1BRD4 | |
| SCHEMBL1542750 | 0.80 | CYP3A4 (0.56) | CYP3A4TRPV1PDPK1BRD4IKBKB | |
| SCHEMBL1542749 | 0.80 | CYP3A4 (0.56) | CYP3A4TRPV1PDPK1BRD4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307372-B1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2012-04-25 | — | — | EP | claimed |
| EP-2307372-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2011-04-13 | — | — | EP | claimed |
| WO-2010010017-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-28 | — | — | WO | claimed |
| US-20100021423-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2010-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100021423-A1 | Heterocyclic antiviral compounds | POLR2A, RRM2B, RRP1B | CYP3A4 528/4885TRPV1 4645/4885PIP4K2A 2030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.