Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | ANPEP | P15144 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427969 | 0.85 | ALDH1A1 (0.70) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL3427705 | 0.82 | ALDH1A1 (0.74) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL4414127 | 0.81 | ALDH1A1 (0.77) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL10143960 | 0.81 | ALDH1A1 (0.77) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1543865 | 0.81 | GRM5 (0.53) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1543196 | 0.80 | GRM5 (0.64) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1116630 | 0.79 | ALDH1A1 (0.78) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL27368115 | 0.79 | GRM5 (0.62) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1543355 | 0.79 | GRM5 (0.52) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| Piperidine SCHEMBL3246198 | 0.77 | ALDH1A1 (0.67) | GRM5ALDH1A1L3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307377-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Limited (GB) | 2011-04-13 | — | — | EP | disclosed |