Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543353 | 0.79 | GRM5 (0.64) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3090984 | 0.79 | HPGDS (0.51) | GRM5 | |
| SCHEMBL3090998 | 0.79 | HPGDS (0.51) | GRM5 | |
| SCHEMBL1543865 | 0.78 | GRM5 (0.53) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL14490487 | 0.77 | HTT (0.53) | ALDH1A1L3MBTL1MAPTSMN1; SMN2HTT | |
| SCHEMBL3427969 | 0.75 | ALDH1A1 (0.70) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3427705 | 0.72 | ALDH1A1 (0.74) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL28788248 | 0.71 | THRB (0.51) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL10143960 | 0.71 | ALDH1A1 (0.77) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL4414127 | 0.71 | ALDH1A1 (0.77) | GRM5ALDH1A1L3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307377-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Limited (GB) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153720-A1 | NICOTINAMIDE DERIVATIVES | PFIZER LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |