Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.45 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | GALR2 | O43603 | 1/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953406 | 1.00 | EPHX2 (0.50) | EPHX2KIF11GABBR2GABBR1MMP12 | |
| SCHEMBL15434091 | 1.00 | EPHX2 (0.50) | EPHX2KIF11GABBR2GABBR1MMP12 | |
| SCHEMBL2172826 | 0.87 | EPHX2 (0.51) | EPHX2GALR2GALR1EPHX1SYK | |
| SCHEMBL12953404 | 0.86 | EPHX2 (0.56) | EPHX2KIF11GABBR2GABBR1GALR2 | |
| SCHEMBL15434097 | 0.86 | PIM1 (0.53) | EPHX2KIF11GABBR2GABBR1GALR2 | |
| SCHEMBL12953553 | 0.86 | PIM1 (0.53) | EPHX2KIF11GABBR2GABBR1GALR2 | |
| SCHEMBL15434096 | 0.86 | PIM1 (0.53) | EPHX2KIF11GABBR2GABBR1GALR2 | |
| SCHEMBL12953129 | 0.85 | EPHX2 (0.58) | EPHX2KIF11GABBR2GABBR1GALR2 | |
| SCHEMBL1333239 | 0.82 | GABBR2 (0.49) | EPHX2KIF11GABBR2GABBR1MMP12 | |
| SCHEMBL12127078 | 0.82 | GABBR2 (0.49) | EPHX2KIF11GABBR2GABBR1MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633245-B2 | PAI-1 inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2014-01-21 | — | — | US | disclosed |