Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 7/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28535602 | 0.97 | ATM (0.43) | ATMCTSKPPARACTSSHDAC4 | |
| SCHEMBL30096598 | 0.97 | ATM (0.43) | ATMCTSKPPARACTSSHDAC4 | |
| SCHEMBL31232348 | 0.92 | ATM (0.45) | ATMCTSKPPARACTSSPPARG | |
| SCHEMBL5220048 | 0.92 | ATM (0.45) | ATMCTSKPPARACTSSPPARG | |
| SCHEMBL15434434 | 0.89 | MAPT (0.48) | ATMCTSKMAPTSYKALDH1A1 | |
| SCHEMBL20514687 | 0.89 | MMP1 (0.34) | PPARAALDH1A1TSHR | |
| SCHEMBL20514686 | 0.89 | MMP1 (0.34) | PPARAALDH1A1TSHR | |
| SCHEMBL20514702 | 0.89 | MAPT (0.45) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL20514703 | 0.89 | MAPT (0.45) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL31048296 | 0.88 | ATM (0.45) | ATMCTSKPPARACTSSPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079834-B2 | HIV protease inhibitors | MERCK CANADA INC. (CA) | 2015-07-14 | — | — | US | disclosed |
| US-20140018325-A1 | HIV PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018325-A1 | HIV PROTEASE INHIBITORS | PRSS1, SERPINB1, FURIN | ATM 2390/4885CTSK 78/4885PPARA 4236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.