Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 4/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880918 | 0.77 | PDK1 (0.35) | ACHEPARP1TNKS2PARP2 | |
| SCHEMBL15434699 | 0.76 | PDK1 (0.34) | ACHEPARP1TNKS2PARP2 | |
| SCHEMBL9284199 | 0.76 | PDK1 (0.34) | ACHEEEF2KPARP1TNKS2PARP2 | |
| SCHEMBL15434696 | 0.73 | PDK1 (0.33) | PARP1TNKS2PARP2 | |
| SCHEMBL15434636 | 0.72 | MAPK1 (0.34) | PARP1TNKS2PARP2 | |
| SCHEMBL9287302 | 0.70 | KDM4E (0.55) | ACHEEEF2KPARP1TNKS2PARP2 | |
| SCHEMBL16479770 | 0.70 | PDK1 (0.39) | ACHEEEF2KPARP1TNKS2PARP2 | |
| SCHEMBL16461411 | 0.67 | ACHE (0.33) | ACHECNR2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL856576 | 0.66 | ACHE (0.38) | ACHEMAPTCACNA1GCACNA1HCACNA1I | |
| SCHEMBL857347 | 0.66 | PDK1 (0.33) | ACHEEEF2KPARP1TNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140107100-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140073628-A1 | BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE | RICE KENNETH D (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140018347-A1 | BENZOXAZEPINES AS INHIBITORS OF mTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018347-A1 | BENZOXAZEPINES AS INHIBITORS OF mTOR AND METHODS OF THEIR USE AND MANUFACTURE | MTOR, RICTOR, RPTOR | ALOX15 670/4885ACHE 4069/4885NPSR1 1254/4885 |
| US-20140107100-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | ALOX15 585/4885ACHE 3487/4885NPSR1 1460/4885 |
| US-20140073628-A1 | BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE | MTOR, RPTOR, RICTOR | ALOX15 4164/4885ACHE 4635/4885NPSR1 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.