Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | DUT | P33316 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15435113 | 0.86 | F9 (0.41) | DUTFFAR1MMP13CYP11B2 | |
| SCHEMBL28410297 | 0.73 | CYP11B2 (0.55) | FFAR1CYP11B2 | |
| SCHEMBL15435128 | 0.71 | CYP11B2 (0.53) | CYP11B2 | |
| SCHEMBL12001681 | 0.69 | ACACB (0.82) | ACACBMMP2MMP13MMP1MMP3 | |
| SCHEMBL745723 | 0.69 | CYP11B2 (0.53) | CYP11B2 | |
| SCHEMBL3746927 | 0.69 | CYP11B2 (0.51) | CYP11B2 | |
| SCHEMBL31261551 | 0.68 | PTGS2 (0.64) | RXRARXRBFFAR1 | |
| SCHEMBL3742114 | 0.68 | CYP11B2 (0.49) | CYP11B2 | |
| SCHEMBL20490376 | 0.66 | HDAC4 (0.51) | RXRARXRBFFAR1 | |
| SCHEMBL30385599 | 0.65 | CYP11B2 (0.47) | CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429995-B1 | ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2014-01-22 | — | — | EP | disclosed |