Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CCR6 | P51684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275025 | 0.84 | ALDH1A1 (0.34) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL14493863 | 0.82 | ALDH1A1 (0.33) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10225364 | 0.68 | NPC1 (0.31) | — | |
| SCHEMBL24553235 | 0.62 | KDM4E (0.47) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL275429 | 0.61 | DGAT1 (0.38) | MAPTALDH1A1KDM4EHSD17B10HTT | |
| SCHEMBL11563077 | 0.59 | MAPT (0.52) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13217488 | 0.59 | KDM4E (0.43) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL28999329 | 0.57 | HPGD (0.41) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL17165495 | 0.57 | SMN1; SMN2 (0.48) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11008658 | 0.56 | ALDH1A1 (0.62) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957077-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2014-01-22 | — | — | EP | disclosed |