Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70671 | 0.88 | TNKS (0.37) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL69730 | 0.87 | HTR1A (0.40) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL70462 | 0.85 | HTR1A (0.41) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL70516 | 0.84 | HTR1A (0.39) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL69752 | 0.82 | HTR1A (0.34) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL68426 | 0.82 | HTR1A (0.34) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL71347 | 0.81 | HTR1A (0.34) | HTR1AHTR7TNKSTNKS2GRIA2 | |
| SCHEMBL68684 | 0.80 | HTR1A (0.40) | HTR1AHTR7TNKSTNKS2SPR | |
| SCHEMBL69946 | 0.80 | ALDH1A1 (0.42) | HTR1AHTR7TNKSTNKS2ALDH1A1 | |
| SCHEMBL71000 | 0.80 | HTR1A (0.39) | HTR1AHTR7TNKSTNKS2SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209791-B1 | Heterocyclic derivatives | MERCK SHARP & DOHME (NL) | 2014-01-22 | — | — | EP | disclosed |