SCHEMBL15436504

SCHEMBL15436504

C=C(OCC)c1nc(C#N)cn1COCC[Si](C)(C)C

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 7/20 0.34
RPS6KB1 P23443 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1857062 0.86 DGAT1 (0.38) DGAT1
SCHEMBL1858741 0.81 DGAT1 (0.37) DGAT1
SCHEMBL2934571 0.80 DGAT1 (0.36) DGAT1
SCHEMBL15471710 0.79 DGAT1 (0.39) DGAT1
Potassium Ion SCHEMBL1857290 0.79 DGAT1 (0.36) DGAT1
SCHEMBL12000815 0.79 DGAT1 (0.39) DGAT1RPS6KB1
SCHEMBL13735417 0.77 DGAT1 (0.41) DGAT1
SCHEMBL27318486 0.76 DGAT1 (0.37) DGAT1RPS6KB1
SCHEMBL1858224 0.75 DGAT1 (0.41) DGAT1RPS6KB1
SCHEMBL10291486 0.75 DGAT1 (0.36) DGAT1RPS6KB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2687516-A1 Inhibitors of C-FMS Kinase Janssen Pharmaceutica N.V. (BE) 2014-01-22 EP disclosed