Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.34 |
| ▸ | MEN1 | O00255 | 7/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10199606 | 1.00 | ALDH1A1 (0.37) | ALDH1A1POLBUSP2MAPK1HAVCR2 | |
| SCHEMBL15437018 | 1.00 | ALDH1A1 (0.37) | ALDH1A1POLBUSP2MAPK1HAVCR2 | |
| SCHEMBL2721188 | 0.86 | RXFP1 (0.32) | ALDH1A1MEN1KMT2ARXFP1NPSR1 | |
| SCHEMBL2717472 | 0.86 | RXFP1 (0.32) | ALDH1A1MEN1KMT2ARXFP1NPSR1 | |
| SCHEMBL2721186 | 0.86 | RXFP1 (0.32) | ALDH1A1MEN1KMT2ARXFP1NPSR1 | |
| SCHEMBL2720744 | 0.77 | HAVCR2 (0.50) | ALDH1A1POLBUSP2MAPK1HAVCR2 | |
| SCHEMBL4104549 | 0.71 | PIK3CD (0.39) | POLBNR1H2NR1H3MEN1KMT2A | |
| SCHEMBL34469097 | 0.70 | POLB (0.46) | ALDH1A1POLBLMNACYP2C19SMN1; SMN2 | |
| SCHEMBL31409963 | 0.69 | PLAU (0.38) | ALDH1A1POLB | |
| SCHEMBL23526516 | 0.69 | LMNA (0.33) | ALDH1A1POLBUSP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031355-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031355-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, SSB, MALT1 | ALDH1A1 3702/4885POLB 3908/4885USP2 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.