Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bretylium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | THPO | P40225 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bretylium SCHEMBL29688247 | 1.00 | LMNA (0.65) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL542733 | 1.00 | LMNA (0.65) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL16398024 | 0.98 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL6314565 | 0.98 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL6227453 | 0.98 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL29387750 | 0.98 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL428588 | 0.83 | LMNA (0.50) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL40898 | 0.81 | LMNA (1.00) | LMNACYP2D6CYP3A4MAPK1THPO | |
| SCHEMBL31658959 | 0.80 | CHRM2 (0.50) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL2638385 | 0.78 | MAPK1 (0.62) | LMNACYP2D6CYP3A4MAPK1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4042 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250213647-A1 | CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE | UNIVERSITY OF SOUTH FLORIDA | 2025-07-03 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| WO-2025049064-A9 | CARDIOPROTECTIVE LIPIDS AND METHODS OF USE | SIGNPATH PHARMA INC. (US) | 2025-05-22 | — | — | WO | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| US-20250082688-A1 | COMPOSITIONS AND METHODS FOR WILLIAMS SYNDROME (WS) THERAPY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-03-13 | — | — | US | claimed |
| WO-2025049064-A2 | CARDIOPROTECTIVE LIPIDS AND METHODS OF USE | SIGNPATH PHARMA INC. (US) | 2025-03-06 | — | — | WO | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| US-12097193-B2 | Methods for the administration of COMT inhibitors | BIAL—PORTELA & CA, S.A. (PT) | 2024-09-24 | — | — | US | claimed |
| US-5036106-A | Antiarrhythmia agents, bretylium tosylate | BACANER MARVIN B (US) | 1991-07-30 | — | — | US | claimed |
| WO-1991009627-A1 | MEDICAMENT FOR TREATMENT OF HEART FAILURE | HEDNER THOMAS (SE) | 1991-07-11 | — | — | WO | claimed |
| WO-1991003234-A1 | DRUG CONTAINING MATRIX | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 1991-03-21 | — | — | WO | claimed |
| WO-1991003099-A1 | COMPRESSED POWDER MEDICAMENTS | ANESTA CORPORATION (US) | 1991-03-07 | — | — | WO | claimed |
| US-4962095-A | Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation | E. R. SQUIBB & SONS, INC. (US) | 1990-10-09 | — | — | US | claimed |
| EP-0383258-A2 | Pharmaceutical compositions for reducing pre and post-ischemic myocardial arrhythmias and fibrillation | E.R. SQUIBB & SONS, INC. (US) | 1990-08-22 | — | — | EP | claimed |
| US-4931464-A | ADMINISTERING ZOFENOPRIL OR ITS SALT | E. R. SQUIBB & SONS, INC. (US) | 1990-06-05 | — | — | US | claimed |
| US-4885173-A | ALLOWING PATIENT TO SUCK LOLLIPOP CONTAINING DRUG, WHICH IS RAPIDLY ABSORBED; REMOVING WHEN SYMPTOMS HAVE BEEN RELIEVED | UNIVERSITY OF UTAH (US) | 1989-12-05 | — | — | US | claimed |
| US-4849227-A | Pharmaceutical compositions | EURASIAM LABORATORIES, INC. (US) | 1989-07-18 | — | — | US | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |