Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bretylium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bretylium SCHEMBL11353818 | 0.88 | CYP2D6 (0.79) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL15438 | 0.81 | LMNA (0.65) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL542733 | 0.81 | LMNA (0.65) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL29688247 | 0.81 | LMNA (0.65) | LMNACYP2D6CYP3A4MAPK1THPO | |
| SCHEMBL11574807 | 0.80 | LMNA (0.67) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Valdecoxib SCHEMBL20771026 | 0.79 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL29387750 | 0.79 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL16398024 | 0.79 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL6227453 | 0.79 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Bretylium SCHEMBL6314565 | 0.79 | LMNA (0.63) | LMNACYP2D6CYP3A4MAPK1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3250 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| US-20250058091-A1 | TREATMENT OF HYPERTENSION BY RENAL VASCULAR DELIVERY OF GUANETHIDINE | MERCATOR MEDSYSTEMS, INC. | 2025-02-20 | — | — | US | claimed |
| US-20240074944-A1 | PECVD COATED PHARMACEUTICAL PACKAGING | OAKTREE FUND ADMINISTRATION, LLC | 2024-03-07 | — | — | US | claimed |
| US-20230303305-A1 | METHOD AND PACKAGE FOR REDUCING THE DEGRADATION OF A DRUG AND/OR EXCIPIENT, E.G. POLYSORBATE STABILIZER, IN A PHARMACEUTICAL PRODUCT | OAKTREE FUND ADMINISTRATION, LLC | 2023-09-28 | — | — | US | claimed |
| EP-4247316-A1 | POLYMER VIALS HAVING STANDARD EXTERNAL DIMENSIONS AND REDUCED INTERNAL VOLUME | SiO2 Medical Products, Inc. (US) | 2023-09-27 | — | — | EP | claimed |
| US-20230277415-A1 | POLYMER VIALS HAVING STANDARD EXTERNAL DIMENSIONS AND REDUCED INTERNAL VOLUME | SIO2 MEDICAL PRODUCTS, INC. | 2023-09-07 | — | — | US | claimed |
| US-20230263957-A1 | ATOMIC LAYER DEPOSITION COATED PHARMACEUTICAL PACKAGING AND IMPROVED SYRINGES AND VIALS, E.G. FOR LYOPHILIZED/COLD-CHAIN DRUGS/VACCINES | OAKTREE FUND ADMINISTRATION, LLC | 2023-08-24 | — | — | US | claimed |
| US-11724860-B2 | Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus | SIO2 MEDICAL PRODUCTS, INC. (US) | 2023-08-15 | — | — | US | claimed |
| US-5036106-A | Antiarrhythmia agents, bretylium tosylate | BACANER MARVIN B (US) | 1991-07-30 | — | — | US | claimed |
| EP-0302065-A4 | PHARMACEUTICAL COMPOSITIONS | — | 1990-09-12 | — | — | EP | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| US-4849227-A | Pharmaceutical compositions | EURASIAM LABORATORIES, INC. (US) | 1989-07-18 | — | — | US | claimed |
| EP-0302065-A1 | PHARMACEUTICAL COMPOSITIONS. | EURASIAM LAB (US) | 1989-02-08 | — | — | EP | claimed |
| CN-87103560-A | Pharmaceutical composition | — | 1988-05-18 | — | — | CN | claimed |
| WO-1987005505-A1 | PHARMACEUTICAL COMPOSITIONS | EURASIAM LABORATORIES, INC. (US) | 1987-09-24 | — | — | WO | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| US-RE29618-E | Suppression of cardiac ventricular fibrillation and cardiac arrhythmias with bretylium tosylate | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1978-04-25 | — | — | US | claimed |