Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 6/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13052911 | 0.74 | CYP11B2 (0.55) | CYP11B1CYP11B2LRRK2MGAMGAA | |
| SCHEMBL16720315 | 0.72 | CDK8 (0.51) | CDK8AXLSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19961720 | 0.72 | RAB9A (0.61) | CYP11B1CYP11B2LRRK2MAPK9MAPK10 | |
| SCHEMBL15562322 | 0.71 | CDK8 (0.46) | CDK8AXLSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL729956 | 0.70 | KDM4E (0.56) | CYP11B1CYP11B2LRRK2MGAMGAA | |
| SCHEMBL30270004 | 0.70 | KDM4E (0.56) | CYP11B1CYP11B2LRRK2MGAMGAA | |
| SCHEMBL100777 | 0.70 | CCNK (0.49) | CDK8AXLLRRK2NUDT1MAPK8 | |
| SCHEMBL21851736 | 0.70 | CYP11B2 (0.51) | CYP11B1CYP11B2LRRK2MGAMGAA | |
| SCHEMBL3347164 | 0.70 | CDK8 (0.49) | CDK8AXLSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27767838 | 0.70 | PIK3CA (0.44) | CDK8AXLSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | PIM1, PIM2, PIM3 | CDK8 572/4885AXL 1265/4885CYP11B1 925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.